4 Reasons to Use Mannitol in Your Formulation
22 Jan 2021
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Mannitol is an inert carrier
Mannitol doesn’t promote acid-base reactions, oxidation, or react with primary amines.
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It has high solubility
Mannitol is highly wettable and can decrease disintegration, assisting the drug release. It can also improve the solubility of poorly soluble APIs.
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Mannitol is non-hygroscopic
Meaning an increased protection against moisture in formulations, an improved chemical/physical stability of formulation and a protection of hydrolysable/moisture sensitive actives.
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Mannitol can be used as a crystal in crystal solid dispersion